PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass

Müller D, Stoll C, Palumbo-Zerr K, Böhm C, Krishnacoumar B, Ipseiz N, Taubmann J, Zimmermann M, Böttcher M, Mougiakakos D, Tuckermann J, Djouad F, Schett G, Scholtysek C, Krönke G (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 8428

Journal Issue: 1

DOI: 10.1038/s41598-020-65305-5

Abstract

Bone turnover, which is determined by osteoclast-mediated bone resorption and osteoblast-mediated bone formation, represents a highly energy consuming process. The metabolic requirements of osteoblast differentiation and mineralization, both essential for regular bone formation, however, remain incompletely understood. Here we identify the nuclear receptor peroxisome proliferator-activated receptor (PPAR) δ as key regulator of osteoblast metabolism. Induction of PPARδ was essential for the metabolic adaption and increased rate in mitochondrial respiration necessary for the differentiation and mineralization of osteoblasts. Osteoblast-specific deletion of PPARδ in mice, in turn, resulted in an altered energy homeostasis of osteoblasts, impaired mineralization and reduced bone mass. These data show that PPARδ acts as key regulator of osteoblast metabolism and highlight the relevance of cellular metabolic rewiring during osteoblast-mediated bone formation and bone-turnover.

Authors with CRIS profile

Dorothea Müller Department of Medicine 3 – Rheumatology and Immunology Christina Böhm Department of Medicine 3 – Rheumatology and Immunology Max Zimmermann Department of Neurosurgery Martin Böttcher Department of Medicine 5 – Haematology and Oncology Dimitrios Mougiakakos Professur für Hämatologie/Onkologie mit dem Schwerpunkt Tumorimmunologie Georg Schett Lehrstuhl für Innere Medizin III Gerhard Krönke Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Centre Hospitalier Universitaire de Montpellier (CHU/CHRU MTP) FR France (FR) Cardiff University GB United Kingdom (GB) Universität Ulm DE Germany (DE)

How to cite

APA:

Müller, D., Stoll, C., Palumbo-Zerr, K., Böhm, C., Krishnacoumar, B., Ipseiz, N.,... Krönke, G. (2020). PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-65305-5

MLA:

Müller, Dorothea, et al. "PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass." Scientific Reports 10.1 (2020).

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