3D printing of piezoelectric barium titanate-hydroxyapatite scaffiolds with interconnected porosity for bone tissue engineering

Polley C, Distler T, Detsch R, Lund H, Springer A, Boccaccini AR, Seitz H (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Materials MDPI

Book Volume: 13

Article Number: 1773

Journal Issue: 7

DOI: 10.3390/MA13071773

Abstract

The prevalence of large bone defects is still a major problem in surgical clinics. It is, thus, not a surprise that bone-related research, especially in the field of bone tissue engineering, is a major issue in medical research. Researchers worldwide are searching for the missing link in engineering bone graft materials that mimic bones, and foster osteogenesis and bone remodeling. One approach is the combination of additive manufacturing technology with smart and additionally electrically active biomaterials. In this study, we performed a three-dimensional (3D) printing process to fabricate piezoelectric, porous barium titanate (BaTiO3) and hydroxyapatite (HA) composite scaffiolds. The printed scaffiolds indicate good cytocompatibility and cell attachment as well as bone mimicking piezoelectric properties with a piezoelectric constant of 3 pC/N. This work represents a promising first approach to creating an implant material with improved bone regenerating potential, in combination with an interconnected porous network and a microporosity, known to enhance bone growth and vascularization.

Authors with CRIS profile

Thomas Distler Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Universität Rostock DE Germany (DE) Universitätsmedizin Rostock DE Germany (DE)

How to cite

APA:

Polley, C., Distler, T., Detsch, R., Lund, H., Springer, A., Boccaccini, A.R., & Seitz, H. (2020). 3D printing of piezoelectric barium titanate-hydroxyapatite scaffiolds with interconnected porosity for bone tissue engineering. Materials, 13(7). https://dx.doi.org/10.3390/MA13071773

MLA:

Polley, Christian, et al. "3D printing of piezoelectric barium titanate-hydroxyapatite scaffiolds with interconnected porosity for bone tissue engineering." Materials 13.7 (2020).

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