The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

Grimm D, Wehland M, Corydon TJ, Richter P, Prasad B, Bauer J, Egli M, Kopp S, Lebert M, Krüger M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Stem Cells Translational Medicine Wiley

DOI: 10.1002/sctm.20-0084

Abstract

A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

Authors with CRIS profile

Peter Richter Lehrstuhl für Zellbiologie Binod Prasad Lehrstuhl für Zellbiologie Michael Lebert Lehrstuhl für Zellbiologie

Involved external institutions

Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Aarhus University DK Denmark (DK) Hochschule Luzern (HSLU) / Lucerne University of Applied Sciences and Arts CH Switzerland (CH) Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry DE Germany (DE)

How to cite

APA:

Grimm, D., Wehland, M., Corydon, T.J., Richter, P., Prasad, B., Bauer, J.,... Krüger, M. (2020). The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. Stem Cells Translational Medicine. https://dx.doi.org/10.1002/sctm.20-0084

MLA:

Grimm, Daniela, et al. "The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells." Stem Cells Translational Medicine (2020).

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