Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation

Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman RL (2002)

Publication Status: Published

Publication Type: Journal article

Publication year: 2002

Journal

Journal of Applied Physiology American Physiological Society

Publisher: AMER PHYSIOLOGICAL SOC

Book Volume: 92

Pages Range: 780-788

Journal Issue: 2

Abstract

The relative contribution of endothelial vasodilating factors to acetylcholine (ACh) mediated vasodilation in the forearm cutaneous microcirculation is unclear. The aims of this study were to investigate the contributions of prostanoids and cutaneous C fibers to basal cutaneous blood flow (CuBF) and ACh-mediated vasodilation. ACh was iontophoresed into the forearm, and cutaneous perfusion was measured by laser-Doppler flowmetry. To inhibit the production of prostanoids, four doses of acetylsalicylic acid (ASA; 81, 648, 972, and 1,944 mg) were administered orally. Cutaneous nerve fibers were blocked with topical anesthesia. Cyclooxygenase inhibition did not change basal CuBF or endothelium-mediated vasodilation to ACh. In contrast, ASA (972 and 1,944 mg) significantly reduced the C-fiber-mediated axon reflex in a dose-dependent fashion. Blockade of C-fiber function significantly reduced axon reflex-mediated vasodilation but did not affect basal CuBF or endothelium-dependent vasodilation. The findings suggest that prostanoids do not contribute significantly to basal CuBF or endothelium-dependent vasodilation in the forearm microcirculation. In contrast, prostanoids are mediators of the ACh-provoked axon reflex.

Authors with CRIS profile

Sonja Kilo Lehrstuhl für Arbeits-, Sozial- und Umweltmedizin Max-Josef Hilz Medizinische Fakultät

Involved external institutions

Harvard University US United States (USA) (US) Justus-Liebig-Universität Gießen DE Germany (DE)

How to cite

APA:

Berghoff, M., Kathpal, M., Kilo, S., Hilz, M.-J., & Freeman, R.L. (2002). Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. Journal of Applied Physiology, 92(2), 780-788.

MLA:

Berghoff, Martin, et al. "Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation." Journal of Applied Physiology 92.2 (2002): 780-788.

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