Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

Azizov V, Dietel K, Steffen F, Dürholz K, Meidenbauer J, Lucas S, Frech M, Omata Y, Tajik N, Knipfer L, Kolenbrander A, Seubert S, Lapuente D, Sokolova MV, Hofmann J, Tenbusch M, Ramming A, Steffen U, Nimmerjahn F, Linker R, Wirtz S, Herrmann M, Temchura V, Sarter K, Schett G, Zaiss M (2020)


Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 11

Article Number: 1998

Journal Issue: 1

DOI: 10.1038/s41467-020-15855-z

Abstract

Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (TFH) cells in vitro and in vivo, thereby exerting immune regulatory and tolerance-inducing properties. Alcohol-exposed mice have reduced Bcl6 and PD-1 expression as well as IL-21 production by TFH cells, preventing proper spatial organization of TFH cells to form TFH:B cell conjugates in germinal centers. This effect is associated with impaired autoantibody formation, and mitigates experimental autoimmune arthritis. By contrast, T cell independent immune responses and passive models of arthritis are not affected by alcohol exposure. These data clarify the immune regulatory and tolerance-inducing effect of alcohol consumption.

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APA:

Azizov, V., Dietel, K., Steffen, F., Dürholz, K., Meidenbauer, J., Lucas, S.,... Zaiss, M. (2020). Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis. Nature Communications, 11(1). https://dx.doi.org/10.1038/s41467-020-15855-z

MLA:

Azizov, Vugar, et al. "Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis." Nature Communications 11.1 (2020).

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