Greening the esterification between isosorbide and acetic acid

Inayat A, van Assche A, Clark JH, Farmer TJ (2018)


Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2018

Journal

Book Volume: 7

Pages Range: 41-49

URI: https://www.sciencedirect.com/science/article/pii/S2352554117300542#!

DOI: 10.1016/j.scp.2017.10.004

Open Access Link: https://reader.elsevier.com/reader/sd/pii/S2352554117300542?token=C0502A170EA31A27FCC466EA32FC70B20BD0BBC484243F4B4ADA0B1AF3872999C11A696940DF7D56E7EBE8A7DD3E6E67

Abstract

This contribution deals with the investigation of greener conditions for the preparation of 2,5-diacetyl-isosorbide from the bio-based substances isosorbide and acetic acid. The influence of solvent, catalyst and reactant ratio on the course of the isosorbide conversion and selectivity to 2,5-diacetyl-isosorbide as well as to the intermediate 2-acetyl-isosorbide is examined. It was found that the conventionally used solvent toluene can be substituted by the greener solvent n-propyl acetate. Additionally, the homogeneous acid catalyst p-toluene sulfonic acid can be replaced by the heterogeneous catalyst Amberlyst-15, resulting in an easier isolation of the desired 2,5-diacetyl-isosorbide, this being an important precursor for the vasodilatory drug isosorbide-5-nitrate.

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How to cite

APA:

Inayat, A., van Assche, A., Clark, J.H., & Farmer, T.J. (2018). Greening the esterification between isosorbide and acetic acid. Sustainable Chemistry and Pharmacy, 7, 41-49. https://doi.org/10.1016/j.scp.2017.10.004

MLA:

Inayat, Alexandra, et al. "Greening the esterification between isosorbide and acetic acid." Sustainable Chemistry and Pharmacy 7 (2018): 41-49.

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