Inayat A, van Assche A, Clark JH, Farmer TJ (2018)
Publication Language: English
Publication Type: Journal article, Original article
Publication year: 2018
Book Volume: 7
Pages Range: 41-49
URI: https://www.sciencedirect.com/science/article/pii/S2352554117300542#!
DOI: 10.1016/j.scp.2017.10.004
Open Access Link: https://reader.elsevier.com/reader/sd/pii/S2352554117300542?token=C0502A170EA31A27FCC466EA32FC70B20BD0BBC484243F4B4ADA0B1AF3872999C11A696940DF7D56E7EBE8A7DD3E6E67
This contribution deals with the investigation of greener conditions for the preparation of 2,5-diacetyl-isosorbide from the bio-based substances isosorbide and acetic acid. The influence of solvent, catalyst and reactant ratio on the course of the isosorbide conversion and selectivity to 2,5-diacetyl-isosorbide as well as to the intermediate 2-acetyl-isosorbide is examined. It was found that the conventionally used solvent toluene can be substituted by the greener solvent n-propyl acetate. Additionally, the homogeneous acid catalyst p-toluene sulfonic acid can be replaced by the heterogeneous catalyst Amberlyst-15, resulting in an easier isolation of the desired 2,5-diacetyl-isosorbide, this being an important precursor for the vasodilatory drug isosorbide-5-nitrate.
APA:
Inayat, A., van Assche, A., Clark, J.H., & Farmer, T.J. (2018). Greening the esterification between isosorbide and acetic acid. Sustainable Chemistry and Pharmacy, 7, 41-49. https://dx.doi.org/10.1016/j.scp.2017.10.004
MLA:
Inayat, Alexandra, et al. "Greening the esterification between isosorbide and acetic acid." Sustainable Chemistry and Pharmacy 7 (2018): 41-49.
BibTeX: Download