Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants

Ion R, Necula MG, Mazare AV, Mitran V, Neacsu P, Schmuki P, Cimpean A (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Current Medicinal Chemistry Bentham Science Publishers

Book Volume: 27

Pages Range: 854-902

Journal Issue: 6

DOI: 10.2174/0929867326666190726123229

Abstract

TiO2 nanotubes (TNTs) are attractive nanostructures for localized drug delivery. Owing to their excellent biocompatibility and physicochemical properties, numerous functionalizations of TNTs have been attempted for their use as therapeutic agent delivery platforms. In this review, we discuss the current advances in the applications of TNT-based delivery systems with an emphasis on the various functionalizations of TNTs for enhancing osteogenesis at the bone-implant interface and for preventing implant-related infection. Innovation of therapies for enhancing osteogenesis still represents a critical challenge in regeneration of bone defects. The overall concept focuses on the use of osteoconductive materials in combination with the use of osteoinductive or osteopromotive factors. In this context, we highlight the strategies for improving the functionality of TNTs, using five classes of bioactive agents: growth factors (GFs), statins, plant derived molecules, inorganic therapeutic ions/nanoparticles (NPs) and antimicrobial compounds.

Authors with CRIS profile

Anca Valentina Mazare Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

University of Bucharest / Universitatea din București RO Romania (RO)

How to cite

APA:

Ion, R., Necula, M.G., Mazare, A.V., Mitran, V., Neacsu, P., Schmuki, P., & Cimpean, A. (2020). Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants. Current Medicinal Chemistry, 27(6), 854-902. https://dx.doi.org/10.2174/0929867326666190726123229

MLA:

Ion, Raluca, et al. "Drug Delivery Systems Based on Titania Nanotubes and Active Agents for Enhanced Osseointegration of Bone Implants." Current Medicinal Chemistry 27.6 (2020): 854-902.

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