Recent advances in practical methods for liver cell biology: A short overview
Torres S, Abdullah Z, Brol MJ, Hellerbrand C, Fernandez M, Fiorotto R, Klein S, Königshofer P, Liedtke C, Lotersztajn S, Nevzorova YA, Schierwagen R, Reiberger T, Uschner FE, Tacke F, Weiskirchen R, Trebicka J (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 21
Article Number: 2027
Journal Issue: 6
DOI: 10.3390/ijms21062027
Abstract
Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.
Authors with CRIS profile
Involved external institutions
Universitätsklinikum Aachen (UKA)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Yale School of Medicine
United States (USA) (US)
Charité - Universitätsmedizin Berlin
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Centre de Recherche sur l'Inflammation (CRI)
France (FR)
Universitätsklinikum Bonn
Germany (DE)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Yale School of Medicine
United States (USA) (US)
Charité - Universitätsmedizin Berlin
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Centre de Recherche sur l'Inflammation (CRI)
France (FR)
Universitätsklinikum Bonn
Germany (DE)
Universitat de Barcelona (UB) / University of Barcelona
Spain (ES)
How to cite
APA:
Torres, S., Abdullah, Z., Brol, M.J., Hellerbrand, C., Fernandez, M., Fiorotto, R.,... Trebicka, J. (2020). Recent advances in practical methods for liver cell biology: A short overview. International Journal of Molecular Sciences, 21(6). https://dx.doi.org/10.3390/ijms21062027
MLA:
Torres, Sandra, et al. "Recent advances in practical methods for liver cell biology: A short overview." International Journal of Molecular Sciences 21.6 (2020).
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