The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells

Ilić K, Selmani A, Milić M, Glavan TM, Zapletal E, Ćurlin M, Yokosawa T, Vrček IV, Pavičić I (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Nanoparticle Research Springer Verlag (Germany)

Book Volume: 22

Article Number: 71

Journal Issue: 3

DOI: 10.1007/s11051-020-04791-0

Abstract

Skin protection against ultraviolet (UV) radiation is necessary to reduce sunburn damage (erythema) and has been recognized as an important preventive measure against the development of cancer. Many sun-blocking pharmaceutical products are based on titanium dioxide nanomaterials (TiO2 NMs) due to their UV barrier properties. This study aimed to assess if the UV protective efficiency of TiO2 NMs depends on their shape. We prepared TiO2 nanowires (TNW), TiO2 nanotubes (TNT), and TiO2 nanoplates (TNP) and tested their effects on human keratinocytes before and after UVB irradiation under in vitro exposure settings. The UVB radiation was applied at the dose equivalent to the UV component observed in one medial erythemal dose. The biological effects of TiO2 NMs on nonirradiated and UVB-irradiated keratinocytes were observed by means of cell viability, genotoxicity, and inflammatory response. The obtained results clearly showed that the effects of TiO2 NMs in vitro, either cytotoxic or protective, depend on their shape. These observations highlight the beneficial properties of nanomaterials that can improve the quality and efficacy of nano-enabled products only if the safe-by-design concept has been implemented during the innovation process.

Authors with CRIS profile

Tadahiro Yokosawa Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)

Involved external institutions

Institute for Medical Research and Occupational Health HR Croatia (HR) University of Zagreb / Sveučilište u Zagrebu HR Croatia (HR) Rudjer Boskovic Institute (RBI) / Institut Ruđer Bošković (IRB) HR Croatia (HR)

How to cite

APA:

Ilić, K., Selmani, A., Milić, M., Glavan, T.M., Zapletal, E., Ćurlin, M.,... Pavičić, I. (2020). The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells. Journal of Nanoparticle Research, 22(3). https://dx.doi.org/10.1007/s11051-020-04791-0

MLA:

Ilić, Krunoslav, et al. "The shape of titanium dioxide nanomaterials modulates their protection efficacy against ultraviolet light in human skin cells." Journal of Nanoparticle Research 22.3 (2020).

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