Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations among Older People. Preliminary Results of the Project "Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)"

Corsonello A, Roller-Wirnsberger R, Wirnsberger G, Arnlov J, Carlsson AC, Tap L, Mattace-Raso F, Formiga F, Moreno-Gonzalez R, Weingart C, Sieber C, Kostka T, Guligowska A, Gil P, Lainez Martinez S, Artzi-Medvedik R, Melzer I, Lattanzio F (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Journal of Clinical Medicine MDPI

Book Volume: 9

Journal Issue: 2

DOI: 10.3390/jcm9020294

Abstract

We aimed at investigating to what extent CKD may be staged interchangeably by three different eGFR equations in older people, and evaluating the source of discrepancies among equations in a population of 2257 patients older than 75 years enrolled in a multicenter observational study. eGFR was calculated by CKD-EPI, BIS and FAS equations. Statistical analysis was carried out by Bland-Altman analysis. kappa statistic was used to quantify the agreement between equations in classifying CKD stages. The impact of selected variables on the difference among equations was graphically explored. The average difference between BIS and FAS was -0.24 (95% limits of agreement (95%LA = -4.64-4.14) mL/min/1.73 m(2). The difference between CKD-EPI and BIS and between CKD-EPI and FAS was 8.97 (95%LA = -2.90-20.84) and 8.72 (95%LA = -2.11-19.56) mL/min/1.73 m(2), respectively. As regards CKD stage classification, kappa value was 0.47 for both CKD-EPI vs. FAS and CKD-EPI vs. BIS, while BIS and FAS had similar classificatory properties (kappa = 0.90). Muscle mass was found related to the difference between CKD-EPI and BIS (R-2 = 0.11) or FAS (R-2 = 0.14), but not to the difference between BIS and FAS. In conclusion, CKD-EPI and BIS/FAS equations are not interchangeable to assess eGFR among older people. Muscle mass may represent a relevant source of discrepancy among eGFR equations.

Authors with CRIS profile

Cornel Sieber Lehrstuhl für Innere Medizin (Geriatrie)

Involved external institutions

Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב IL Israel (IL) Medical University of Łódź / Uniwersytet Medyczny w Łodzi PL Poland (PL) Hospital Clínico San Carlos ES Spain (ES) Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA) IT Italy (IT) Bellvitge University Hospital / Hospital Universitari de Bellvitge ES Spain (ES) Uppsala University SE Sweden (SE) Erasmus University Medical Center (MC) NL Netherlands (NL)

How to cite

APA:

Corsonello, A., Roller-Wirnsberger, R., Wirnsberger, G., Arnlov, J., Carlsson, A.C., Tap, L.,... Lattanzio, F. (2020). Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations among Older People. Preliminary Results of the Project "Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)". Journal of Clinical Medicine, 9(2). https://dx.doi.org/10.3390/jcm9020294

MLA:

Corsonello, Andrea, et al. "Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations among Older People. Preliminary Results of the Project "Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)"." Journal of Clinical Medicine 9.2 (2020).

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