An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity
Albert I, Boehm H, Albert M, Feiler CE, Imkampe J, Wallmeroth N, Brancato C, Raaymakers TM, Oome S, Zhang H, Krol E, Grefen C, Gust AA, Chai J, Hedrich R, Van Den Ackerveken G, Nuernberger T (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 1
Article Number: 15140
Abstract
Plants and animals employ innate immune systems to cope with microbial infection. Pattern-triggered immunity relies on the recognition of microbe-derived patterns by pattern recognition receptors (PRRs). Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) constitute plant immunogenic patterns that are unique, as these proteins are produced by multiple prokaryotic (bacterial) and eukaryotic (fungal, oomycete) species. Here we show that the leucine-rich repeat receptor protein (LRR-RP) RLP23 binds in vivo to a conserved 20-amino-acid fragment found in most NLPs (nlp20), thereby mediating immune activation in Arabidopsis thaliana. RLP23 forms a constitutive, ligand-independent complex with the LRR receptor kinase (LRR-RK) SOBIR1 (Suppressor of Brassinosteroid insensitive 1 (BRI1)-associated kinase (BAK1)-interacting receptor kinase 1), and recruits a second LRR-RK, BAK1, into a tripartite complex upon ligand binding. Stable, ectopic expression of RLP23 in potato (Solanum tuberosum) confers nlp20 pattern recognition and enhanced immunity to destructive oomycete and fungal plant pathogens, such as Phytophthora infestans and Sclerotinia sclerotiorum. PRRs that recognize widespread microbial patterns might be particularly suited for engineering immunity in crop plants.
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Additional Organisation(s)
Involved external institutions
Eberhard Karls Universität Tübingen
Germany (DE)
Universiteit Utrecht (UU) / Utrecht University
Netherlands (NL)
Tsinghua University
China (CN)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Germany (DE)
Universiteit Utrecht (UU) / Utrecht University
Netherlands (NL)
Tsinghua University
China (CN)
Julius-Maximilians-Universität Würzburg
Germany (DE)
How to cite
APA:
Albert, I., Boehm, H., Albert, M., Feiler, C.E., Imkampe, J., Wallmeroth, N.,... Nuernberger, T. (2015). An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nature Plants, 1. https://doi.org/10.1038/nplants.2015.140
MLA:
Albert, Isabell, et al. "An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity." Nature Plants 1 (2015).
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