Elevated systemic Il-10 levels indicate immunodepression leading to nosocomial infections after aneurysmal subarachnoid hemorrhage (SAH) in patients
Chaudhry SR, Kahlert UD, Kinfe TM, Lamprecht A, Niemelä M, Hänggi D, Muhammad S (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 21
Article Number: 1569
Journal Issue: 5
DOI: 10.3390/ijms21051569
Abstract
Background: Aneurysmal subarachnoid hemorrhage (SAH) is a highly complex disease with very high mortality and morbidity. About one-third of SAH patients suffer from systemic infections, predominantly pneumonia, that can contribute to excess mortality after SAH. Immunodepression is probably the most important mechanism leading to infections. Interleukin-10 (IL-10) is a master regulator of immunodepression, but it is still not clear if systemic IL-10 levels contribute to immunodepression, occurrence of infections and clinical outcome after SAH. Methods: This explorative study included 76 patients with SAH admitted to our neurointensive care unit within 24 h after ictus. A group of 24 patients without any known intracranial pathology were included as controls. Peripheral venous blood was withdrawn on day 1 and day 7 after SAH. Serum was isolated by centrifugation and stored at −80 °C until analysis. Serum IL-10 levels were determined by enzyme-linked immunoassay (ELISA). Patient characteristics, post-SAH complications and clinical outcome at discharge were retrieved from patients’ record files. Results: Serum IL-10 levels were significantly higher on day 1 and day 7 in SAH patients compared to controls. Serum IL-10 levels were significantly higher on day 7 in patients who developed any kind of infection, cerebral vasospasm (CVS) or chronic hydrocephalus. Serum IL-10 levels were significantly higher in SAH patients discharged with poor clinical outcome (modified Rankin Scale (mRS) 3–6 or Glasgow Outcome Scale (GOS) 1–3). Conclusion: Serum IL-10 might be an additional useful parameter along with other biomarkers to predict post-SAH infections.
Authors with CRIS profile
Thomas Mehari Kinfe
Professur für Neurochirurgie mit dem Schwerpunkt Funktionelle Stereotaktische Neurochirurgie
Involved external institutions
Universitätsklinikum Bonn
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Helsingin yliopisto / University of Helsinki
Finland (FI)
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Helsingin yliopisto / University of Helsinki
Finland (FI)
How to cite
APA:
Chaudhry, S.R., Kahlert, U.D., Kinfe, T.M., Lamprecht, A., Niemelä, M., Hänggi, D., & Muhammad, S. (2020). Elevated systemic Il-10 levels indicate immunodepression leading to nosocomial infections after aneurysmal subarachnoid hemorrhage (SAH) in patients. International Journal of Molecular Sciences, 21(5). https://dx.doi.org/10.3390/ijms21051569
MLA:
Chaudhry, Shafqat Rasul, et al. "Elevated systemic Il-10 levels indicate immunodepression leading to nosocomial infections after aneurysmal subarachnoid hemorrhage (SAH) in patients." International Journal of Molecular Sciences 21.5 (2020).
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