Wetzl M, Sanders JC, Kuwert T, Ritt P (2018)
Publication Type: Journal article
Publication year: 2018
DOI: 10.1007/s12350-018-1272-1
BACKGROUND: The SMARTZOOM multifocal collimator from Siemens Healthcare was developed to improve the γ-photon sensitivity in myocardial perfusion imaging without truncating the field of view. As part of the IQ-SPECT package, it may be used to reduce radiopharmaceutical dose to patients, as well as acquisition time. The aim of this study was twofold: (1) to evaluate the influence of dose reduction in semi-automated MPI scoring, with focus on different strategies for the choice of normal data (count-matched, full-count), and (2) to evaluate the effect of dose reduction afforded by Siemens' IQ-SPECT package. METHODS: 50 patients underwent Tc-99m-sestamibi one-day stress/rest SPECT/CT. Multiple levels of count reduction were generated using binomial thinning. Using Corridor 4DM, summed stress score (SSS) was calculated using either count-matched or full-count normal data. Studies were classified as low-risk (SSS < 4) or intermediate/high-risk (SSS ≥ 4). RESULTS: Count reduction using count-matched normal data increases false-normal rate and decreases sensitivity. With full-count normal data, count reduction increases false-hypoperfusion rate, leading to decreased specificity. Altogether, rate of reclassification was significant at roughly 67% dose and below. CONCLUSION: Significant bias results from count level of normal data relative to actual patient data. Compared to standard LEHR, IQ-SPECT should allow for significant dose reduction.
APA:
Wetzl, M., Sanders, J.C., Kuwert, T., & Ritt, P. (2018). Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT. Journal of Nuclear Cardiology. https://dx.doi.org/10.1007/s12350-018-1272-1
MLA:
Wetzl, Matthias, et al. "Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT." Journal of Nuclear Cardiology (2018).
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