Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents
Fares M, McCosker PM, Alsherbiny MA, Willis AC, Clark T, Neyts J, Jochmans D, Keller PA (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 10
Pages Range: 5191-5195
Journal Issue: 9
DOI: 10.1039/d0ra00257g
Abstract
Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Authors with CRIS profile
Involved external institutions
NICM Health Research Institute
Australia (AU)
University of Wollongong (UOW)
Australia (AU)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Australian National University (ANU)
Australia (AU)
Australia (AU)
University of Wollongong (UOW)
Australia (AU)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Australian National University (ANU)
Australia (AU)
How to cite
APA:
Fares, M., McCosker, P.M., Alsherbiny, M.A., Willis, A.C., Clark, T., Neyts, J.,... Keller, P.A. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10(9), 5191-5195. https://dx.doi.org/10.1039/d0ra00257g
MLA:
Fares, Mohamed, et al. "Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-: A] pyrimidines as potential anti-chikungunya agents." RSC Advances 10.9 (2020): 5191-5195.
BibTeX: Download