Porous silicon nanoparticles for applications in nano-medicine

Hasanzadeh Kafshgari M, Voelcker NH, Harding FJ (2019)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2019

Publisher: Elsevier

Edited Volumes: Comprehensive Nanoscience and Nanotechnology

Series: Reference Module in Materials Science and Materials Engineering

Book Volume: 1-5

Pages Range: 211-226

DOI: 10.1016/B978-0-12-803581-8.10463-1

Abstract

Drug delivery using nanosized materials holds significant potential to resolve challenges faced by conventional enteral and parental therapeutic administration, including poor drug solubility and off-target toxic effects. Porous silicon (pSi) nanostructures possess large surface areas in relation to volume and exhibit high biocompatibility. Tunable pore size and versatile surface functionalisation allows carriers to be created to match drug characteristics, maximising loading capacity. This chapter reviews the fabrication of pSi nanoparticles and their use for targeted drug delivery. Particular emphasis is placed on surface functionalisation regimes typically employed to construct biocompatible nanoparticles. The qualification of candidate pSi nanoparticles as biocompatible and fit-for-purpose, required for progression to therapeutic use, are discussed. We particularly focus on the application of pSi nanocarriers for cancer therapies and chronic wound healing.

Authors with CRIS profile

Morteza Hasanzadeh Kafshgari Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

Monash University AU Australia (AU)

How to cite

APA:

Hasanzadeh Kafshgari, M., Voelcker, N.H., & Harding, F.J. (2019). Porous silicon nanoparticles for applications in nano-medicine. In David L. Andrews, Robert H. Lipson, Thomas Nann (Eds.), Comprehensive Nanoscience and Nanotechnology. (pp. 211-226). Elsevier.

MLA:

Hasanzadeh Kafshgari, Morteza, Nicolas H. Voelcker, and Frances J. Harding. "Porous silicon nanoparticles for applications in nano-medicine." Comprehensive Nanoscience and Nanotechnology. Ed. David L. Andrews, Robert H. Lipson, Thomas Nann, Elsevier, 2019. 211-226.

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