Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
Mandino F, Cerri DH, Garin CM, Straathof M, van Tilborg GA, Chakravarty MM, Dhenain M, Dijkhuizen RM, Gozzi A, Heß A, Keilholz SD, Lerch JP, Shih YYI, Grandjean J (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 13
Article Number: 78
Abstract
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve between-lab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science.
Authors with CRIS profile
Involved external institutions
Italian Institute of Technology / Istituto Italiano di Tecnologia (IIT)
Italy (IT)
University of North Carolina at Chapel Hill
United States (USA) (US)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Singapore Bioimaging Consortium (SBIC)
Singapore (SG)
The Hospital for Sick Children (SickKids)
Canada (CA)
Institut de biologie François Jacob
France (FR)
Emory University
United States (USA) (US)
McGill University
Canada (CA)
Italy (IT)
University of North Carolina at Chapel Hill
United States (USA) (US)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Singapore Bioimaging Consortium (SBIC)
Singapore (SG)
The Hospital for Sick Children (SickKids)
Canada (CA)
Institut de biologie François Jacob
France (FR)
Emory University
United States (USA) (US)
McGill University
Canada (CA)
How to cite
APA:
Mandino, F., Cerri, D.H., Garin, C.M., Straathof, M., van Tilborg, G.A., Chakravarty, M.M.,... Grandjean, J. (2020). Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization. Frontiers in Neuroinformatics, 13. https://dx.doi.org/10.3389/fninf.2019.00078
MLA:
Mandino, Francesca, et al. "Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization." Frontiers in Neuroinformatics 13 (2020).
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