Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

Barro-Soria R, Caicedo A, Jaegle H, Merkel L, Zhao N, Knop G, Gierke K, Dannullis A, Castrop H, Brandstätter JH, Kirchhoff F, Feigenspan A, Strauss O (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 9

DOI: 10.1038/s41598-019-55380-8

Abstract

Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca2+ transients. Compared to wild type, Ca2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca2+-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca2+ signaling within the central nervous system.

Authors with CRIS profile

Gabriel Knop Lehrstuhl für Tierphysiologie Kaspar Gierke Lehrstuhl für Tierphysiologie Johann Helmut Brandstätter Lehrstuhl für Tierphysiologie Andreas Feigenspan Professur für Neurobiologie

Involved external institutions

University of Miami US United States (USA) (US) Universitätsklinikum Regensburg DE Germany (DE) Universität des Saarlandes (UdS) DE Germany (DE) Universität Regensburg DE Germany (DE)

How to cite

APA:

Barro-Soria, R., Caicedo, A., Jaegle, H., Merkel, L., Zhao, N., Knop, G.,... Strauss, O. (2019). Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells. Scientific Reports, 9. https://dx.doi.org/10.1038/s41598-019-55380-8

MLA:

Barro-Soria, Rene, et al. "Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells." Scientific Reports 9 (2019).

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