miR-488-5p and its role in melanoma

Arnold J, Engelmann JC, Schneider N, Boßerhoff AK, Kuphal S (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Experimental and Molecular Pathology Elsevier

Book Volume: 112

DOI: 10.1016/j.yexmp.2019.104348

Abstract

Due to their ability to regulate dozens to hundreds of target genes simultaneously and, therefore, influence several oncogenic pathways at the same time, microRNAs are a fascinating research object in melanoma. MicroRNAs have been identified as regulators of tumor proliferation, invasion and metastasis in melanoma. More precisely, it has been published that dysregulation of miR-488 contibutes to the progression of several cancer entities. However, the biological functions of miR-488, in special miR-488-5p in melanoma, remain unclear. This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as a tumor suppressor. Transfection of miR-488-5p mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis. These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue.

Authors with CRIS profile

Nadja Schneider Lehrstuhl für Biochemie und Molekulare Medizin Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin Silke Kuphal Lehrstuhl für Biochemie und Molekulare Medizin

Involved external institutions

Royal Netherlands Institute for Sea Research (NIOZ)

Netherlands (NL)

How to cite

APA:

Arnold, J., Engelmann, J.C., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2019). miR-488-5p and its role in melanoma. Experimental and Molecular Pathology, 112. https://dx.doi.org/10.1016/j.yexmp.2019.104348

MLA:

Arnold, Jessica, et al. "miR-488-5p and its role in melanoma." Experimental and Molecular Pathology 112 (2019).

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