Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation

Xu J, Liu N, Wu D, Gao Z, Song YY, Schmuki P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

ACS nano American Chemical Society

DOI: 10.1021/acsnano.9b05386

Abstract

The low penetration depth of UV light in mammalian tissue is the critical limitation for the use of TiO2-based photocatalysis in biomedical applications. In this work, we develop an effective near-infrared (NIR)-active photocatalytic platform that consists of a shell structure of upconversion nanocrystals decorated on a core of Au/dark-TiO2. The heart of this system is the strong photocatalytic activity in the visible region enabled by the gold surface-plasmon resonance on dark TiO2 (D-TiO2). Simulation and experiment demonstrate for an optimized Au/D-TiO2 combination a highly enhanced light absorption in the visible range. Using ampicillin sodium (AMP) as model drug, we exemplify the effective use of this principle by demonstrating a NIR light-triggered photocatalytic payload release. Importantly, the photocatalytically generated reactive oxygen species can effectively inactivate AMP-resistant bacteria strains, thus maintaining an antibacterial effect even after all drug is released. Overall, we anticipate that the here-introduced NIR-light-active photocatalytic cascade can considerably widen TiO2-based photocatalysis and its applications into the infrared range.

Authors with CRIS profile

Ning Liu Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

Ocean University of China / 中国海洋大学 CN China (CN)

How to cite

APA:

Xu, J., Liu, N., Wu, D., Gao, Z., Song, Y.Y., & Schmuki, P. (2020). Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation. ACS nano. https://dx.doi.org/10.1021/acsnano.9b05386

MLA:

Xu, Jingwen, et al. "Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation." ACS nano (2020).

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