Dose–response relationship between physical activity and mortality in adults with noncommunicable diseases: A systematic review and meta-analysis of prospective observational studies

Geidl W, Schlesinger S, Mino E, Miranda L, Pfeifer K (2020)

Publication Language: English

Publication Status: Submitted

Publication Type: Journal article, Review article

Future Publication Type: Journal article

Publication year: 2020

Journal

International Journal of Behavioral Nutrition and Physical Activity BioMed Central

Book Volume: 17

Article Number: 109

URI: https://rdcu.be/b6snH

DOI: 10.1186/s12966-020-01007-5

Open Access Link: https://rdcu.be/b6snH

Abstract

Abstract

Background

This study aims to investigate the relationship between post-diagnosis physical activity and mortality in patients with selected noncommunicable diseases, including breast cancer, lung cancer, type 2 diabetes, ischemic heart disease, stroke, chronic obstructive pulmonary disease (COPD), osteoarthritis, low back pain and major depressive disorders.

Methods

A systematic search was conducted of PubMed, Scopus and the Web of Science from their inception to August 2018. Additionally, the search was updated in August 2019. Eligibility criteria included prospective observational studies examining the relationship between at least three physical activity categories (e.g. low, moderate, high) and all-cause mortality as the primary outcome.

Results

In total, 28 studies were included in the meta-analysis: 12 for breast cancer, 6 for type 2 diabetes, 8 for ischemic heart disease and two for COPD. The linear meta-analysis revealed that each 10 metabolic equivalent tasks hours increase of physical activity per week was associated with a 22% lower mortality rate in breast cancer patients (Summary Hazard Ratio [HR], 0.78; 95% CI: 0.71, 0.86; I2: 90.1 %), 12% in ischemic heart disease patients (HR, 0.88; 95% CI: 0.83, 0.93; I2: 86.5% ), 30% in COPD patients (HR, 0.70; 95% CI: 0.45, 1.09; I2: 94%) and 4% in type 2 diabetes patients (HR, 0.96; 95% CI: 0.93, 0.99; I2: 71.8%). There was indicationevidence of a non-linear association with mortality risk reductions even for low levels of activity, as well as a flattening of the curve at higher levels of activity. The certainty of evidence was lowmoderate for breast cancer, T2D and IHD but only very low for COPD.

 

Conclusion

Higher levels of post-diagnosis physical activity are associated with lower mortality rates in breast cancer, type 2 diabetes, ischemic heart disease and COPD patients, with indicationevidence of a no-threshold and non-linear dose–response pattern.

Authors with CRIS profile

Wolfgang Geidl Lehrstuhl für Sportwissenschaft mit dem Schwerpunkt Bewegung und Gesundheit Eriselda Mino Lehrstuhl für Sportwissenschaft mit dem Schwerpunkt Bewegung und Gesundheit Klaus Pfeifer Lehrstuhl für Sportwissenschaft mit dem Schwerpunkt Bewegung und Gesundheit

How to cite

APA:

Geidl, W., Schlesinger, S., Mino, E., Miranda, L., & Pfeifer, K. (2020). Dose–response relationship between physical activity and mortality in adults with noncommunicable diseases: A systematic review and meta-analysis of prospective observational studies. International Journal of Behavioral Nutrition and Physical Activity, 17. https://dx.doi.org/10.1186/s12966-020-01007-5

MLA:

Geidl, Wolfgang, et al. "Dose–response relationship between physical activity and mortality in adults with noncommunicable diseases: A systematic review and meta-analysis of prospective observational studies." International Journal of Behavioral Nutrition and Physical Activity 17 (2020).

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