miR-488-5p and its role in melanoma

Arnold J, Engelmann JC, Schneider N, Boßerhoff AK, Kuphal S (2020)


Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 112

Article Number: 104348

DOI: 10.1016/j.yexmp.2019.104348

Abstract

Due to their ability to regulate dozens to hundreds of target genes simultaneously and, therefore, influence several oncogenic pathways at the same time, microRNAs are a fascinating research object in melanoma. MicroRNAs have been identified as regulators of tumor proliferation, invasion and metastasis in melanoma. More precisely, it has been published that dysregulation of miR-488 contibutes to the progression of several cancer entities. However, the biological functions of miR-488, in special miR-488-5p in melanoma, remain unclear. This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as a tumor suppressor. Transfection of miR-488-5p mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis. These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue.

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How to cite

APA:

Arnold, J., Engelmann, J.C., Schneider, N., Boßerhoff, A.K., & Kuphal, S. (2020). miR-488-5p and its role in melanoma. Experimental and Molecular Pathology, 112. https://doi.org/10.1016/j.yexmp.2019.104348

MLA:

Arnold, Jessica, et al. "miR-488-5p and its role in melanoma." Experimental and Molecular Pathology 112 (2020).

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