Impact of Fc gamma R variants on the response to alemtuzumab in multiple sclerosis

Keller CW, Ruck T, Mchugh D, Pfeuffer S, Gross CC, Korsukewitz C, Melzer N, Klotz L, Meuth SG, Muenz C, Nimmerjahn F, Wiendl H, Luenemann JD (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Annals of Clinical and Translational Neurology Wiley

DOI: 10.1002/acn3.50935

Abstract

Allelic variants of genes encoding for the Fc gamma receptors IIIA and IIA have been associated with the clinical response to cell-depleting antibodies in lymphoma patients. Here, we tested the hypothesis that FCGR3A and FCGR2A high-affinity polymorphisms predict clinical outcomes to alemtuzumab therapy in 85 patients with relapsing-remitting multiple sclerosis. No differences in clinical and MRI-based efficacy parameters, the development of severe infusion-associated reactions and secondary autoimmune diseases during a 2 year follow-up was observed based on FCGR3A or FCGR2A polymorphisms. This study does not support the use of FCGR genetic variants to predict clinical outcomes to alemtuzumab.

Authors with CRIS profile

Falk Nimmerjahn Lehrstuhl für Genetik

Involved external institutions

Universitätsklinikum Münster DE Germany (DE) University of Zurich / Universität Zürich (UZH) CH Switzerland (CH)

How to cite

APA:

Keller, C.W., Ruck, T., Mchugh, D., Pfeuffer, S., Gross, C.C., Korsukewitz, C.,... Luenemann, J.D. (2019). Impact of Fc gamma R variants on the response to alemtuzumab in multiple sclerosis. Annals of Clinical and Translational Neurology. https://dx.doi.org/10.1002/acn3.50935

MLA:

Keller, Christian W., et al. "Impact of Fc gamma R variants on the response to alemtuzumab in multiple sclerosis." Annals of Clinical and Translational Neurology (2019).

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