Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling.

Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K (2019)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2019

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 9

Pages Range: 16312

Journal Issue: 1

DOI: 10.1038/s41598-019-52540-8

Abstract

R heteroreceptor complexes illustrates the complexity of receptor-receptor interactions and their potential of modifying cell responses to external stimuli. Therefore, GPCR heteromers may provide a very promising novel target for the therapy of neuropsychiatric disorders.

Authors with CRIS profile

Michael Plach Professur für Molekulare und Klinische Pharmazie Thorsten Schäfer Professur für Molekulare und Klinische Pharmazie Dorothée Weikert Lehrstuhl für Pharmazeutische Chemie Peter Gmeiner Lehrstuhl für Pharmazeutische Chemie Kristina Friedland Professur für Molekulare und Klinische Pharmazie

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

Involved external institutions

Karolinska Institute SE Sweden (SE)

How to cite

APA:

Plach, M., Schäfer, T., Borroto-Escuela, D.O., Weikert, D., Gmeiner, P., Fuxe, K., & Friedland, K. (2019). Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling. Scientific Reports, 9(1), 16312. https://dx.doi.org/10.1038/s41598-019-52540-8

MLA:

Plach, Michael, et al. "Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling." Scientific Reports 9.1 (2019): 16312.

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