Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells

Klein S, Smuda M, Harreiß C, Menter C, Distel L, Kryschi C (2019)

Publication Type: Journal article

Publication year: 2019

Journal

ACS Applied Materials and Interfaces American Chemical Society

DOI: 10.1021/acsami.9b13877

Abstract

Bifunctional Au-Fe3O4 nanoheterodimers were synthesized by thermally decomposing Fe(III)oleate on gold nanoparticles followed by functionalizing with tiron, 2,3-dihydroxybenzoic acid, or caffeic acid. These catechol derivatives are antioxidative and thus are predicted to function as superoxide scavengers. In particular, caffeic acid lost its antioxidant capacity, although it was covalently linked through its carboxyl moiety to the Fe3O4 surface. Tiron was shown to bind via its catechol group to the Au-Fe3O4 nanoheterodimers, and 2,3-dihydroxybenzoic was just physisorbed between the oleic acid surface structures. Caffeic-acid stabilized Au-Fe3O4 nanoheterodimers turned out to act as X-ray protector in healthy cells but as X-ray enhancing agents in cancer cells. Furthermore, these functionalized Au-Fe3O4 nanoheterodimers were found to inhibit the migratory capacity of the cancer cells.

Authors with CRIS profile

Stefanie Klein Professur für Physikalische Chemie Christina Harreiß Lehrstuhl für Physikalische Chemie I Luitpold Distel Department of Radiation Oncology Carola Kryschi Professur für Physikalische Chemie

How to cite

APA:

Klein, S., Smuda, M., Harreiß, C., Menter, C., Distel, L., & Kryschi, C. (2019). Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells. ACS Applied Materials and Interfaces. https://dx.doi.org/10.1021/acsami.9b13877

MLA:

Klein, Stefanie, et al. "Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells." ACS Applied Materials and Interfaces (2019).

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