Interactions of a short hyaluronan chain with a phospholipid membrane

Bełdowski P, Yuvan S, Dėdinaitė A, Claesson PM, Pöschel T (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Colloids and Surfaces B: Biointerfaces Elsevier

Book Volume: 184

Article Number: 110539

DOI: 10.1016/j.colsurfb.2019.110539

Abstract

Hyaluronic acid and phospholipids are two components that are present in the synovial fluid, and both are implicated as important facilitators of joint lubrication. In this work we aim to clarify how hyaluronic acid interacts with a phospholipid bilayer through their molecular interactions at the bilayer surface. To this end we performed molecular dynamics simulations of one hyaluronic acid molecule at a phospholipid bilayer in aqueous solution. The simulations were carried out for two aqueous solutions of equal concentrations, containing either NaCl or CaCl2. We analyzed hydrogen bonds, hydrophobic contacts and cation mediated bridges to clarify how hyaluoronic acid binds to a phospholipid bilayer. The analysis shows that calcium ions promote longer lasting bonds between the species as they create calcium ion bridges between the carboxylate group of hyaluronic acid and the phosphate group of the phospholipid. This type of additional bonding does not significantly influence the total number of contact created, but rather stabilizes the contact. The presented results can facilitate understanding of the role of hyaluronic acid and phospholipid interactions in terms of lubrication of articular cartilage.

Authors with CRIS profile

Thorsten Pöschel Lehrstuhl für Multiscale Simulation of Particulate Systems

Involved external institutions

University of Technology and Life Sciences in Bydgoszcz / Uniwersytet Technologiczno-Przyrodniczy im. Jana i Jędrzeja Śniadeckich w Bydgoszczy (UTP) PL Poland (PL) East Carolina University US United States (USA) (US) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) SE Sweden (SE)

How to cite

APA:

Bełdowski, P., Yuvan, S., Dėdinaitė, A., Claesson, P.M., & Pöschel, T. (2019). Interactions of a short hyaluronan chain with a phospholipid membrane. Colloids and Surfaces B: Biointerfaces, 184. https://doi.org/10.1016/j.colsurfb.2019.110539

MLA:

Bełdowski, Piotr, et al. "Interactions of a short hyaluronan chain with a phospholipid membrane." Colloids and Surfaces B: Biointerfaces 184 (2019).

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