Diffusive Mobile MC for Controlled-Release Drug Delivery with Absorbing Receiver

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Details zur Publikation

Autorinnen und Autoren: Cao TN, Ahmadzadeh A, Jamali Kooshkghazi V, Wicke W, Yeoh PL, Evans J, Schober R
Herausgeber: IEEE
Jahr der Veröffentlichung: 2019
ISBN: 978-1-5386-8088-9
ISSN: 1938-1883
Sprache: Englisch


Abstract

Nanoparticle drug carriers play an important role in facilitating efficient targeted drug delivery, i.e., improving treatment success and reducing drug costs and side effects. However, the mobility of nanoparticle drug carriers poses a challenge in designing drug delivery systems. Moreover, healing results critically depend on the rate and time duration of drug absorption. Therefore, in this paper, we aim to design a controlled-release drug delivery system with a mobile drug carrier that minimizes the total amount of released drugs while ensuring a desired rate of drug absorption during a prescribed time period. We model the mobile drug carrier as a mobile transmitter, the targeted diseased cells as an absorbing receiver, and the channel between the transceivers as a time-variant channel since the carrier mobility results in a time-variant absorption rate of the drug molecules. Based on this, we develop a molecular communication (MC) framework to design the controlled-release drug delivery system. In particular, we develop new analytical expressions for the mean, variance, probability density function, and cumulative distribution function of the channel impulse response (CIR). Equipped with the statistical analysis of the CIR, we design and evaluate the performance of the controlled-release drug delivery system. Numerical results show significant savings in the amount of released drugs compared to a constant-release rate design and reveal the necessity of accounting for drug carrier mobility for reliable drug delivery.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Ahmadzadeh, Arman
Lehrstuhl für Digitale Übertragung
Cao, Trang Ngoc
Professur für Informationsübertragung
Jamali Kooshkghazi, Vahid Dr.-Ing.
Lehrstuhl für Digitale Übertragung
Schober, Robert Prof. Dr.-Ing.
Lehrstuhl für Digitale Übertragung
Wicke, Wayan
Lehrstuhl für Digitale Übertragung
Yeoh, Phee Lep
Lehrstuhl für Digitale Übertragung


Einrichtungen weiterer Autorinnen und Autoren

The University of Melbourne


Zitierweisen

APA:
Cao, T.N., Ahmadzadeh, A., Jamali Kooshkghazi, V., Wicke, W., Yeoh, P.L., Evans, J., & Schober, R. (2019). Diffusive Mobile MC for Controlled-Release Drug Delivery with Absorbing Receiver. In IEEE (Eds.), Proceedings of the ICC 2019 - 2019 IEEE International Conference on Communications (ICC). Shanghai, CN.

MLA:
Cao, Trang Ngoc, et al. "Diffusive Mobile MC for Controlled-Release Drug Delivery with Absorbing Receiver." Proceedings of the ICC 2019 - 2019 IEEE International Conference on Communications (ICC), Shanghai Ed. IEEE, 2019.

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Zuletzt aktualisiert 2019-12-08 um 07:14