Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects

Diba M, Camargo WA, Zinkevich T, Grünewald A, Detsch R, Kabiri Y, Kentgens APM, Boccaccini AR, Van Den Beucken JJJP, Leeuwenburgh SCG (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Materials Chemistry B Royal Society of Chemistry

Book Volume: 7

Pages Range: 796-808

Journal Issue: 5

DOI: 10.1039/c8tb03062f

Abstract

Osteoporosis is the most widespread metabolic bone disease which represents a major public health burden. Consequently, novel biomaterials with a strong capacity to regenerate osteoporotic bone defects are urgently required. In view of the anti-osteoporotic and osteopromotive efficacy of alendronate and 45S5 bioactive glass, respectively, we investigated the feasibility to synthesize novel hybrid particles by exploiting the strong interactions between these two compounds. Herein, we demonstrate the facile preparation of a novel class of hybrid particles of tunable morphology, chemical composition and structure. These hybrid particles (i) release alendronate and various inorganic elements (Ca, Na, Si, and P) in a controlled manner, (ii) exhibit a strong anti-osteoclastic effect in vitro, and (iii) stimulate regeneration of osteoporotic bone in vivo. Consequently, this novel class of hybrid biomaterials opens up new avenues of research on the design of bone substitutes with specific activity to facilitate regeneration of bone defects in osteoporotic patients.

Authors with CRIS profile

Alina Grünewald Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Radboud University Nijmegen NL Netherlands (NL) Delft University of Technology (TU Delft) NL Netherlands (NL)

How to cite

APA:

Diba, M., Camargo, W.A., Zinkevich, T., Grünewald, A., Detsch, R., Kabiri, Y.,... Leeuwenburgh, S.C.G. (2019). Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects. Journal of Materials Chemistry B, 7(5), 796-808. https://dx.doi.org/10.1039/c8tb03062f

MLA:

Diba, Mani, et al. "Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects." Journal of Materials Chemistry B 7.5 (2019): 796-808.

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