Role of melanoma inhibitory activity in melanocyte senescence

Feuerer L, Lamm S, Henz I, Kappelmann-Fenzl M, Haferkamp S, Meierjohann S, Hellerbrand C, Kuphal S, Boßerhoff AK (2019)

Publication Type: Journal article

Publication year: 2019

Journal

DOI: 10.1111/pcmr.12801

Abstract

The protein melanoma inhibitory activity (MIA) is known to be expressed in melanoma and to support melanoma progression. Interestingly, previous studies also observed the expression of MIA in nevi. Concentrating on these findings, we revealed that MIA expression is correlated with a senescent state in melanocytes. Induction of replicative or oncogene-induced senescence resulted in increased MIA expression in vitro. Notably, MIA knockdown in senescent melanocytes reduced the percentage of senescence-associated beta-Gal-positive cells and enhanced proliferation. Using the melanoma mouse model Tg(Grm1), MIA-deficient mice supported the impact of MIA on senescence by showing a significantly earlier tumor onset compared to controls. In melanocytes, MIA knockdown led to a downregulation of the cell cycle inhibitor p21 in vitro and in vivo. In contrast, after induction of hTERT in human melanoma cells, p21 regulation by MIA was lost. In summary, our data show for the first time that MIA is a regulator of cellular senescence in human and murine melanocytes.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Regensburg Germany (DE) Fraunhofer-Institut für Biomedizinische Technik (IBMT) / Fraunhofer Institute for Biomedical Engineering Germany (DE)

How to cite

APA:

Feuerer, L., Lamm, S., Henz, I., Kappelmann-Fenzl, M., Haferkamp, S., Meierjohann, S.,... Boßerhoff, A.K. (2019). Role of melanoma inhibitory activity in melanocyte senescence. Pigment Cell & Melanoma Research. https://dx.doi.org/10.1111/pcmr.12801

MLA:

Feuerer, Lena, et al. "Role of melanoma inhibitory activity in melanocyte senescence." Pigment Cell & Melanoma Research (2019).

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