Mechanistic insight on the chemistry of potential Pt antitumor agents as revealed by collaborative research performed in Kragujevac and Erlangen
Petrović B, Jovanović S, Puchta R, van Eldik R (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 495
Article Number: 118953
DOI: 10.1016/j.ica.2019.06.004
Abstract
This personal account reports on the mechanistic insight gained on the chemistry of potential Pt antitumor agents based on the collaborative research between the groups of Živadin Bugarčić in Kragujevac (Serbia) and Rudi van Eldik in Erlangen (Germany). The work focuses on different mononuclear Pt(II) and Pt(IV), as well as dinuclear Pt(II) complexes, the tuning of their lability through steric and electronic (σ-donor and π-acceptor) effects, their interaction with sulfur- and nitrogen-donor bio-relevant nucleophiles, the elucidation of structure-reactivity relationships, and DFT calculations on ground, transition and product state complexes. It presents an overview of the investigated systems and reveals mechanistic information on the basis of spectroscopic and kinetic measurements.
Authors with CRIS profile
Ralph Puchta
Professur für Paläontologie (Schwerpunkt Faziesanalyse)
Rudi van Eldik
Naturwissenschaftliche Fakultät
Involved external institutions
Serbia (RS)How to cite
APA:
Petrović, B., Jovanović, S., Puchta, R., & van Eldik, R. (2019). Mechanistic insight on the chemistry of potential Pt antitumor agents as revealed by collaborative research performed in Kragujevac and Erlangen. Inorganica Chimica Acta, 495. https://doi.org/10.1016/j.ica.2019.06.004
MLA:
Petrović, Biljana, et al. "Mechanistic insight on the chemistry of potential Pt antitumor agents as revealed by collaborative research performed in Kragujevac and Erlangen." Inorganica Chimica Acta 495 (2019).
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