[18F]Fluorine-Labeled Pharmaceuticals: Direct Aromatic Fluorination Compared to Multi-Step Strategies

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Details zur Publikation

Autorinnen und Autoren: Krüll J, Heinrich M
Zeitschrift: Asian Journal of Organic Chemistry
Jahr der Veröffentlichung: 2019
Band: 8
Heftnummer: 5
Seitenbereich: 576-590
ISSN: 2193-5807
eISSN: 2193-5815


Positron emission tomography (PET) presents an important tool for medicinal and pharmaceutical investigations, with applications ranging from fundamental research to the diagnosis of a broad variety of diseases. Crucial for the use of this technique is, however, a robust labeling strategy for the preparation of the required radiolabeled compound. For 18-fluorine-labeling, which represents the most widely applied method in this field, it is interesting to note that a kind of paradigm change occurred over the last years. While multi-step labeling strategies were the preferred approach for many decades, mainly due to the lack of suitable leaving groups for direct [
F]fluorination reactions, the synthetic tools to achieve the highly attractive direct 18-fluorine-labeling rapidly increased recently. This focus review points out a comparison between the multi-step approaches and the newly developed direct fluorination strategies available for nucleophilic 18-fluorination of carbocyclic aromatic systems, including a discussion of advantages and limitations.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Heinrich, Markus Prof. Dr.
Professur für Pharmazeutische Chemie
Krüll, Jasmin
Professur für Pharmazeutische Chemie


Krüll, J., & Heinrich, M. (2019). [18F]Fluorine-Labeled Pharmaceuticals: Direct Aromatic Fluorination Compared to Multi-Step Strategies. Asian Journal of Organic Chemistry, 8(5), 576-590. https://dx.doi.org/10.1002/ajoc.201800494

Krüll, Jasmin, and Markus Heinrich. "[18F]Fluorine-Labeled Pharmaceuticals: Direct Aromatic Fluorination Compared to Multi-Step Strategies." Asian Journal of Organic Chemistry 8.5 (2019): 576-590.


Zuletzt aktualisiert 2019-28-05 um 09:23