Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study
Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SL, Sieber C, Cederholm T, Bautmans I (2019)
Publication Type: Journal article
Publication year: 2019
Journal
DOI: 10.1007/s40520-019-01208-4
Abstract
Background: A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. Aim: To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Methods: Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4–9) and a body mass index of 20–30 kg/m 2 were randomly allocated to two daily servings of active (n = 137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n = 151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH)D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression. Results: IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks. Conclusions: We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations.
Authors with CRIS profile
Involved external institutions
Uppsala University Hospital / Akademiska sjukhuset
Sweden (SE)
Università degli studi "La Sapienza"
Italy (IT)
Free University Medical Center / VU Medisch Centrum
Netherlands (NL)
Danone Nutricia Research
Netherlands (NL)
Vrije Universiteit Brussel (VUB)
Belgium (BE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
University of Parma / Università degli Studi di Parma
Italy (IT)
Newcastle University
United Kingdom (GB)
Sweden (SE)
Università degli studi "La Sapienza"
Italy (IT)
Free University Medical Center / VU Medisch Centrum
Netherlands (NL)
Danone Nutricia Research
Netherlands (NL)
Vrije Universiteit Brussel (VUB)
Belgium (BE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
University of Parma / Università degli Studi di Parma
Italy (IT)
Newcastle University
United Kingdom (GB)
How to cite
APA:
Liberman, K., Njemini, R., Luiking, Y., Forti, L.N., Verlaan, S., Bauer, J.M.,... Bautmans, I. (2019). Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-019-01208-4
MLA:
Liberman, Keliane, et al. "Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study." Aging Clinical and Experimental Research (2019).
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