Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity

Journal article

Publication Details

Author(s): Soldatovic TV, Selimovic E, Smit B, Asanin D, Planojevic NS, Markovic SD, Puchta R, Alzoubi BM
Journal: Journal of Coordination Chemistry
Publication year: 2019
Volume: 72
Journal issue: 4
Pages range: 690-706
ISSN: 0095-8972
eISSN: 1029-0389


The mechanism of substitution from tetrahedral [ZnCl
(en)] and square-pyramidal [ZnCl
(terpy)] complexes (where en = 1,2-diaminoethane or ethylenediamine and terpy = 2,2′:6′,2′′-terpyridine) by guanosine-5′-monophosphate (5′-GMP) have been investigated by
H NMR spectroscopy. The substitution reaction of [ZnCl
(terpy)] complex is faster than the reaction of [ZnCl
(en)], which was finished after 48 h. Information about the structures of the final products in solution were obtained from the DFT calculations (B3LYP/6-31G(d)) and experimental
H NMR data acquired during the course of the reaction. The cytotoxic activity of zinc(II) complexes was tested on human breast cancer cell line MDA-MB-231, human colon cancer cell line HCT-116 and normal human lung fibroblast cell line MRC-5. Both complexes reduced cell viabilities, while [ZnCl
(terpy)] was significantly cytotoxic on MDA-MB-231 after 72 h, and HCT-116 after 24 h without dose dependence. The differences in reactivity toward 5′-GMP and cytotoxic activity of Zn(II) complexes may be attributed to the very stable square-pyramidal geometry of [ZnCl
(terpy)] in solution, while weak ligand effect of the en compared to the terpy affected slow interaction of tetrahedral [ZnCl
(en)] complex with the target bio-molecule.

FAU Authors / FAU Editors

Puchta, Ralph PD Dr.
Professur für Paläontologie (Schwerpunkt Faziesanalyse)

External institutions with authors

Al-Balqa` Applied University
State University of Novi Pazar
University of Kragujevac

How to cite

Soldatovic, T.V., Selimovic, E., Smit, B., Asanin, D., Planojevic, N.S., Markovic, S.D.,... Alzoubi, B.M. (2019). Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity. Journal of Coordination Chemistry, 72(4), 690-706.

Soldatovic, Tanja V., et al. "Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity." Journal of Coordination Chemistry 72.4 (2019): 690-706.


Last updated on 2019-28-05 at 15:36