Therapeutic efficacy of the Ginkgo special extract EGb761®within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease

Beitrag in einer Fachzeitschrift
(Review-Artikel)


Details zur Publikation

Autorinnen und Autoren: Müller WE, Eckert A, Eckert GP, Fink H, Friedland K, Gauthier S, Hoerr R, Ihl R, Kasper S, Möller HJ
Zeitschrift: World Journal of Biological Psychiatry
Jahr der Veröffentlichung: 2019
Band: 20
Heftnummer: 3
Seitenbereich: 173-189
ISSN: 1562-2975


Abstract

Objectives: The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction as an important common pathomechanism for the whole spectrum of age-associated memory disorders from cognitive symptoms in the elderly over mild cognitive impairment to Alzheimer’s dementia. Thus, a drug such as the Ginkgo special extract EGb 761
®
which improves mitochondrial function should be able to ameliorate cognitive deficits over the whole aging spectrum. Methods: We review the most relevant publications about effects of EGb 761
®
on cognition and synaptic deficits in preclinical studies as well as on cognitive deficits in man from aging to dementia. Results: EGb 761
®
improves mitochondrial dysfunction and cognitive impairment over the whole spectrum of age-associated cognitive disorders in relevant animal models and in vitro experiments, and also shows clinical efficacy in improving cognition over the whole range from aging to Alzheimer’s or even vascular dementia. Conclusions: EGb 761
®
shows clinical efficacy in the treatment of cognitive deficits over the whole spectrum of age-associated memory disorders. Thus, EGb 761
®
can serve as an important pharmacological argument for the mitochondrial cascade hypothesis of dementia.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Friedland, Kristina Prof. Dr.
Professur für Molekulare und Klinische Pharmazie


Einrichtungen weiterer Autorinnen und Autoren

Alexianer Krefeld GmbH
Dr. Willmar Schwabe GmbH & Co. KG
Freie Universität Berlin
Goethe-Universität Frankfurt am Main
Justus-Liebig-Universität Gießen
Ludwig-Maximilians-Universität (LMU)
McGill University
Medizinische Universität Wien


Zitierweisen

APA:
Müller, W.E., Eckert, A., Eckert, G.P., Fink, H., Friedland, K., Gauthier, S.,... Möller, H.J. (2019). Therapeutic efficacy of the Ginkgo special extract EGb761®within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease. World Journal of Biological Psychiatry, 20(3), 173-189. https://dx.doi.org/10.1080/15622975.2017.1308552

MLA:
Müller, Walter E., et al. "Therapeutic efficacy of the Ginkgo special extract EGb761®within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease." World Journal of Biological Psychiatry 20.3 (2019): 173-189.

BibTeX: 

Zuletzt aktualisiert 2019-24-05 um 12:53