Towards In-Vivo X-Ray Nanoscopy: Acquisition Parameters vs. Image Quality

Mill L, Kling L, Grüneboom A, Schett G, Christiansen S, Maier A (2019)

Publication Type: Conference contribution, Conference Contribution

Publication year: 2019

Journal

Informatik aktuell Gesellschaft für Informatik (GI)

Publisher: Springer Berlin Heidelberg

Pages Range: 251-256

Conference Proceedings Title: Informatik aktuell

Event location: Lübeck DE

ISBN: 9783658253257

DOI: 10.1007/978-3-658-25326-4_56

Abstract

X-ray microscopy is a powerful imaging technique that permits the investigation of specimen on nanoscale with resolution of up to 700 nm in 3-D. In the context of bio-medical research this is a promising technology that allows to study the microstructure of biological tissues. However, X-ray microscopy (XRM) systems are not designed for in-vivo applications and are mainly used in the field of material sciences in which dose is irrelevant. High resolution scans may take up to 10 hours. Our long-term goal is to utilize this modality to study the effects of disease dynamics and treatment in-vivo on mice bones. Therefore, a first step towards this ambitious goal is to evaluate the current state-of-the-art to determine the required system parameters. In this work, we investigate the impact of different XRM settings on the image quality. By changing various acquisition parameters such as exposure time, voltage, current and number of projections, we simulate the outcome of XRM scans, while reducing the X-ray energy. We base our simulations on a high resolution ex-vivo scan of a mouse tibia. The resulting reconstructions are evaluated qualitatively as well as quantitatively by calculating the contrast-to-noise ratio (CNR). We demonstrate that we can reach comparable image quality while reducing the total X-ray energy which forms a foundation towards the upcoming experiments.

Authors with CRIS profile

Leonid Mill Lehrstuhl für Informatik 5 (Mustererkennung) Georg Schett Lehrstuhl für Innere Medizin III Andreas Maier Lehrstuhl für Informatik 5 (Mustererkennung)

Related research project(s)

Advancing osteoporosis medicine by observing bone microstructure and remodelling using a fourdimensional nanoscope (4-D nanoSCOPE) Advancing osteoporosis medicine by observing bone microstructure and remodelling using a fourdimensional nanoscope April 1, 2019 - March 31, 2025

Involved external institutions

Helmholtz-Zentrum Berlin für Materialien und Energie (HZB) DE Germany (DE) Freie Universität Berlin DE Germany (DE)

How to cite

APA:

Mill, L., Kling, L., Grüneboom, A., Schett, G., Christiansen, S., & Maier, A. (2019). Towards In-Vivo X-Ray Nanoscopy: Acquisition Parameters vs. Image Quality. In Thomas M. Deserno, Andreas Maier, Christoph Palm, Heinz Handels, Klaus H. Maier-Hein, Thomas Tolxdorff (Eds.), Informatik aktuell (pp. 251-256). Lübeck, DE: Springer Berlin Heidelberg.

MLA:

Mill, Leonid, et al. "Towards In-Vivo X-Ray Nanoscopy: Acquisition Parameters vs. Image Quality." Proceedings of the Workshop on Bildverarbeitung fur die Medizin, 2019, Lübeck Ed. Thomas M. Deserno, Andreas Maier, Christoph Palm, Heinz Handels, Klaus H. Maier-Hein, Thomas Tolxdorff, Springer Berlin Heidelberg, 2019. 251-256.

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