Neutron spectroscopy on protein solutions employing backscattering with an increased energy range

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Beck C, Appel M, Grimaldo M, Roosen-Runge F, Zhang F, Frick B, Schreiber F, Seydel T
Zeitschrift: Physica B-Condensed Matter
Jahr der Veröffentlichung: 2019
Band: 562
Seitenbereich: 31-35
ISSN: 0921-4526


Abstract

Novel cold neutron backscattering spectrometers contribute substantially to the understanding of the diffusive dynamics of proteins in dense aqueous suspensions. Such suspensions are fundamentally interesting for instance in terms of the so-called macromolecular crowding, protein cluster formation, gelation, and self-assembly. Notably, backscattering spectrometers with the highest flux can simultaneously access the center-of-mass diffusion of the proteins and the superimposed internal molecular diffusive motions. The nearly complete absence of protein-protein collisions on the accessible nanosecond observation time scale even in dense protein suspensions implies that neutron backscattering accesses the so-called short-time limit for the center-of-mass diffusion. This limit is particularly interesting in terms of a theoretical understanding by concepts from colloid physics. Here we briefly review recent progress in studying protein dynamics achieved with the latest generation of backscattering spectrometers. We illustrate this progress by the first data from a protein solution using the backscattering-and-time-of-flight option BATS on IN16B at the ILL and we outline future perspectives.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Appel, Markus Dr.
Lehrstuhl für Biophysik


Zusätzliche Organisationseinheit(en)
Zentrum für Medizinische Physik und Technik


Einrichtungen weiterer Autorinnen und Autoren

Eberhard Karls Universität Tübingen
Institute Laue-Langevin (ILL)
Lund University / Lunds universitet


Zitierweisen

APA:
Beck, C., Appel, M., Grimaldo, M., Roosen-Runge, F., Zhang, F., Frick, B.,... Seydel, T. (2019). Neutron spectroscopy on protein solutions employing backscattering with an increased energy range. Physica B-Condensed Matter, 562, 31-35. https://dx.doi.org/10.1016/j.physb.2018.11.058

MLA:
Beck, Christian, et al. "Neutron spectroscopy on protein solutions employing backscattering with an increased energy range." Physica B-Condensed Matter 562 (2019): 31-35.

BibTeX: 

Zuletzt aktualisiert 2019-02-05 um 08:38