Saying NO to H2S: A Story of HNO, HSNO, and SSNO-

Ivanovic-Burmazovic I, Filipovic MR (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Inorganic Chemistry American Chemical Society

Book Volume: 58

Pages Range: 4039-4051

Journal Issue: 7

DOI: 10.1021/acs.inorgchem.8b02592

Abstract

Interactions between small inorganic molecules are fundamental to the understanding of basic reaction mechanisms and some of the initial processes of chemical evolution that preceded organic molecules and led to the origin of life. The kinetics of these processes are suitable for the fast generation of a variety of new chemical entities and the propagation of a cascade of chemical reactions, a property that is ideal for signaling purposes even in biological systems. NO and H2S are such molecules that are nowadays recognized as biological gasotransmitters involved in the regulation of physiological functions through protein modifications such as S-nitrosothiol, disulfide, and persulfide formations. In this Viewpoint, we review the current understanding of interactions of NO (and organic and metal nitrosyl species) with H2S, in both chemical and biochemical contexts. Through the formation of HNO, (H)SNO (and its isomers), (H)SSNO, and polysulfides, these two gasotransmitters initiate reaction networks with significant roles in cell signaling. The chemical reactivities and biological effects of these nitrogen and sulfur species are still unresolved, and, thus, a cross-talk between all of them represents a challenging interdisciplinary field that awaits exciting new findings. We tackle some of the intriguing and open questions and provide perspectives for future research directions.

Authors with CRIS profile

Ivana Ivanovic-Burmazovic Lehrstuhl für Bioanorganische Chemie

Involved external institutions

Institut national de physique nucléaire et de physique des particules (IN2P3) FR France (FR)

How to cite

APA:

Ivanovic-Burmazovic, I., & Filipovic, M.R. (2019). Saying NO to H2S: A Story of HNO, HSNO, and SSNO-. Inorganic Chemistry, 58(7), 4039-4051. https://dx.doi.org/10.1021/acs.inorgchem.8b02592

MLA:

Ivanovic-Burmazovic, Ivana, and Milos R. Filipovic. "Saying NO to H2S: A Story of HNO, HSNO, and SSNO-." Inorganic Chemistry 58.7 (2019): 4039-4051.

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