The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Ray S, Rosenberg M, Chanut-Delalande H, Decaras A, Schwertner B, Toubiana W, Auman T, Schnellhammer I, Teuscher M, Valenti P, Khila A, Klingler M, Payre F
Zeitschrift: eLife
Jahr der Veröffentlichung: 2019
Band: 8
ISSN: 2050-084X


Abstract

Small open reading frames (smORFs) encoding 'micropeptides' exhibit remarkable evolutionary complexity. Conserved peptides encoded by mille-pattes (mlpt)/polished rice (pri)/tarsal less (tal) are essential for embryo segmentation in Tribolium but, in Drosophila, function in terminal epidermal differentiation and patterning of adult legs. Here, we show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitinligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning. We find that loss of segmentation function for this module in flies evolved concomitantly with restriction of Svb expression in early Drosophila embryos. Consistent with this observation, artificially restoring early Svb expression in flies causes segmentation defects that depend on mlpt function, demonstrating enduring potency of an ancestral developmental switch despite evolving embryonic patterning modes. These results highlight the evolutionary plasticity of conserved molecular complexes under the constraints of essential genetic networks.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Klingler, Martin Prof. Dr.
Professur für Zoologie
Ray, Suparna, Ph.D.
Professur für Zoologie
Schnellhammer, Irene
Professur für Zoologie
Schwertner, Barbara
Lehrstuhl für Entwicklungsbiologie
Teuscher, Matthias
Lehrstuhl für Entwicklungsbiologie


Einrichtungen weiterer Autorinnen und Autoren

Hebrew University of Jerusalem
Institut de Génomique Fonctionelle de Lyon igfl
Université Toulouse III - Paul Sabatier


Zitierweisen

APA:
Ray, S., Rosenberg, M., Chanut-Delalande, H., Decaras, A., Schwertner, B., Toubiana, W.,... Payre, F. (2019). The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning. eLife, 8. https://dx.doi.org/10.7554/eLife.39748

MLA:
Ray, Suparna, et al. "The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning." eLife 8 (2019).

BibTeX: 

Zuletzt aktualisiert 2019-09-04 um 22:08