Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model

Li JJ, Akey A, Dunstan C, Vielreicher M, Friedrich O, Bell DC, Zreiqat H (2018)

Publication Language: English

Publication Type: Journal article, Original article

Publication year: 2018

Journal

Advanced Healthcare Materials Wiley

Book Volume: 7

Article Number: e1800218

Journal Issue: 15

DOI: 10.1002/adhm.201800218

Abstract

Extensive bone loss due to trauma or disease leads to impaired healing. Current
bone grafts and substitutes have major drawbacks that limit their effectiveness
for treating large bone defects. A number of bone substitutes in development are 
undergoing preclinical testing, but few studies specifically investigate the in
vivo material-tissue interactions that provide an important indicator to
long-term implant safety and efficacy. This study is the first of its kind to
specifically investigate in vivo material-tissue interactions at the bone-implant
interface. Baghdadite scaffolds implanted in critical-sized segmental defects in 
sheep tibia for 26 weeks are analyzed by focused ion beam scanning electron
microscopy, multiphoton microscopy, and histology. The scaffolds are seen to
induce extensive bone formation that directly abut the implant surfaces with no
evidence of chronic inflammation or fibrous capsule formation. Bone remodeling is
influenced by slow in vivo degradation around and within the implant, causing
portions of the implant to be incorporated into the newly formed bone. These
findings have important implications for predicting the long-term effects of
baghdadite ceramics in promoting defect healing, and support the translation of
baghdadite scaffolds as a new generation of bone graft substitutes with improved 
properties for the repair of large bone defects.

Authors with CRIS profile

Martin Vielreicher Lehrstuhl für Medizinische Biotechnologie Oliver Friedrich Lehrstuhl für Medizinische Biotechnologie

Related research project(s)

PPP Australia - Advanced Bone Tissue Engineering: Ceramic Scaffolds & Biophotonics Jan. 1, 2015 - Dec. 31, 2016

Involved external institutions

Harvard University US United States (USA) (US) University of Sydney (USYD) AU Australia (AU)

How to cite

APA:

Li, J.J., Akey, A., Dunstan, C., Vielreicher, M., Friedrich, O., Bell, D.C., & Zreiqat, H. (2018). Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model. Advanced Healthcare Materials, 7(15). https://dx.doi.org/10.1002/adhm.201800218

MLA:

Li, Jiao Jiao, et al. "Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model." Advanced Healthcare Materials 7.15 (2018).

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