Suppressing non-controlled leakage of hydrophilic payloads from redox-responsive nanocapsules

Hosseinpour S, Behzadi S, Stadler J, Crespy D, Landfester K (2017)

Publication Language: English

Publication Type: Journal article

Publication year: 2017

Journal

Colloids and Surfaces A-Physicochemical and Engineering Aspects Elsevier

Book Volume: 532

Article Number: 2-7

Journal Issue: 5

URI: https://www.sciencedirect.com/science/article/abs/pii/S0927775717307355

DOI: 10.1016/j.colsurfa.2017.07.077

Abstract

Nanocapsules with a hydrophilic core are particularly interesting for biomedical and anticorrosion applications since these nanocontainers allow encapsulating a wide range of hydrophilic payloads and controlling their release profiles. However, a major challenge associated with the preparation of these nanocapsules is the non-controlled leakage of hydrophilic payloads from the core due to osmotic pressure. Herein, we present an approach for the preparation of polymer nanocapsules that suppress the non-controlled leakage of payloads and respond to chemical reduction that triggers release of encapsulated payloads. The non-controlled leakage of hydrophilic payloads from the nanocapsules is hindered by increasing the shell thickness. These nanocapsules consisting of reduction-responsive units possess a remarkable release property only under reductive condition while cease non-controlled leakage of the payload in the aqueous release medium. The described nanocapsules can be applied for biomedical and anticorrosion applications in which triggered release of hydrophilic payloads is suitable.

Authors with CRIS profile

Saman Hosseinpour Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik

Involved external institutions

Max-Planck-Institut für Polymerforschung (MPI-P) / Max Planck Institute for Polymer Research

Germany (DE)

How to cite

APA:

Hosseinpour, S., Behzadi, S., Stadler, J., Crespy, D., & Landfester, K. (2017). Suppressing non-controlled leakage of hydrophilic payloads from redox-responsive nanocapsules. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 532(5). https://dx.doi.org/10.1016/j.colsurfa.2017.07.077

MLA:

Hosseinpour, Saman, et al. "Suppressing non-controlled leakage of hydrophilic payloads from redox-responsive nanocapsules." Colloids and Surfaces A-Physicochemical and Engineering Aspects 532.5 (2017).

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