Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform

Xu J, Zhou X, Gao Z, Song YY, Schmuki P (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Angewandte Chemie International Edition Wiley

Book Volume: 55

Pages Range: 593-597

Journal Issue: 2

DOI: 10.1002/anie.201508710

Abstract

In this work, we use a double-layered stack of TiO2 nanotubes (TiNTs) to construct a visible-light-triggered drug delivery system. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles (AuNPs). The AuNPs allow for a photocatalytic scission of the hydrophobic chain under visible light. To demonstrate this principle, we loaded ampicillin (AMP) into the lower part of the TiO2 nanotube stack, triggered visible-light-induced release, and carried out antibacterial studies. The release from the platform becomes most controllable if the drug is silane-grafted in the hydrophilic bottom layer for drug storage. Thus, visible light photocatalysis can also determine the release kinetics of the active drug from the nanotube wall.

Authors with CRIS profile

Xuemei Zhou Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Additional Organisation(s)

Exzellenz-Cluster Engineering of Advanced Materials

Involved external institutions

Northeastern University US United States (USA) (US)

How to cite

APA:

Xu, J., Zhou, X., Gao, Z., Song, Y.-Y., & Schmuki, P. (2016). Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform. Angewandte Chemie International Edition, 55(2), 593-597. https://dx.doi.org/10.1002/anie.201508710

MLA:

Xu, Jingwen, et al. "Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform." Angewandte Chemie International Edition 55.2 (2016): 593-597.

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