Urban Particulate Matter-Induced Decomposition of S-Nitrosoglutathione Relevant to Aberrant Nitric Oxide Biological Signaling

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Oszajca M, Wadolek A, Hooper J, Brindell M, van Eldik R, Stochel G
Zeitschrift: Chemsuschem
Jahr der Veröffentlichung: 2019
Band: 12
Heftnummer: 3
Seitenbereich: 661-671
ISSN: 1864-5631
eISSN: 1864-564X


Abstract

Exposure to airborne particulate matter (PM) is associated with hazardous effects on human health. Soluble constituents of PM may be released in biological fluids and disturb the precisely tuned nitric oxide signaling processes. The influence of aqueous extracts from two types of airborne urban PM (SRM 1648a, a commercially available sample, and KR PM2.5, a sample collected " in-house" in Krakow, Poland) on the stability of S-nitrosoglutathione (GSNO)was investigated. The particle interfaces had no direct effect on the studied reaction, but extracts obtained from both samples facilitated NO release from GSNO. The effectiveness of NO release was significantly affected by glutathione (GSH) and ascorbic acid (AscA). Examination of the combined influence of Cu2+, Fe3+, and reductants on GSNO stability revealed copper to be the main GSNO decomposing species. Computational models of nitrosothiols interacting with metal oxide substrates and solvated metal ions support these claims. The study stresses the importance of the interplay between metal ions and biological reductants in S-nitrosothiols decomposition.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

van Eldik, Rudi Prof. Dr.
Naturwissenschaftliche Fakultät


Einrichtungen weiterer Autorinnen und Autoren

Jagiellonian University / Uniwersytet Jagielloński (UJ)


Zitierweisen

APA:
Oszajca, M., Wadolek, A., Hooper, J., Brindell, M., van Eldik, R., & Stochel, G. (2019). Urban Particulate Matter-Induced Decomposition of S-Nitrosoglutathione Relevant to Aberrant Nitric Oxide Biological Signaling. Chemsuschem, 12(3), 661-671. https://dx.doi.org/10.1002/cssc.201802201

MLA:
Oszajca, Maria, et al. "Urban Particulate Matter-Induced Decomposition of S-Nitrosoglutathione Relevant to Aberrant Nitric Oxide Biological Signaling." Chemsuschem 12.3 (2019): 661-671.

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Zuletzt aktualisiert 2019-02-05 um 16:49