Quantification of co-, n-, and ad-lupulone in hop-based dietary supplements and phytopharmaceuticals and modulation of their contents by the extraction method

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schulz C, Chiheb C, Pischetsrieder M
Zeitschrift: Journal of Pharmaceutical and Biomedical Analysis
Jahr der Veröffentlichung: 2019
Band: 168
Seitenbereich: 124-132
ISSN: 0731-7085


Abstract

Hop β-bitter acids (lupulones) are health-beneficial components of Humulus lupulus L. showing, for example, antidepressant-like effects in vitro.
Despite of the widespread use of hops for medicinal purposes, the
concentrations of lupulones in hop-based drugs have not been reported
yet. The present study developed, validated, and applied a method with
external calibration, which allows for the first time separate
quantification of co-, n-, and ad-lupulone in hop-based drugs by
UHPLC‒DAD. Concentrations between ‘not detectable’ and 2.7 mg/mL
co-lupulone, 2.2 mg/mL nlupulone, or 0.7 mg/mL ad-lupulone were measured
in nine different commercial dietary supplements and
phytopharmaceuticals. Only one hop tincture contained sufficient
lupulone to possibly exert potential antidepressant effects. Aiming for
products with increased lupulone content, the extraction efficiency of
different solvents was investigated. Complete extraction of lupulones
from raw hops was achieved by organic solvents including methanol and
ethanol, whereas aqueous mixtures resulted in low recovery. These
results indicate that adapted extraction conditions may result in more
effective hops products.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Schulz, Carolin
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)


Zusätzliche Organisationseinheit(en)
Emil-Fischer-Zentrum (Emil Fischer Center)


Zitierweisen

APA:
Schulz, C., Chiheb, C., & Pischetsrieder, M. (2019). Quantification of co-, n-, and ad-lupulone in hop-based dietary supplements and phytopharmaceuticals and modulation of their contents by the extraction method. Journal of Pharmaceutical and Biomedical Analysis, 168, 124-132. https://dx.doi.org/10.1016/j.jpba.2019.02.022

MLA:
Schulz, Carolin, Chafia Chiheb, and Monika Pischetsrieder. "Quantification of co-, n-, and ad-lupulone in hop-based dietary supplements and phytopharmaceuticals and modulation of their contents by the extraction method." Journal of Pharmaceutical and Biomedical Analysis 168 (2019): 124-132.

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Zuletzt aktualisiert 2019-25-02 um 12:53