Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Turan A, Grosche L, Krawczyk A, Mühl-Zürbes P, Drassner C, Düthorn A, Kummer M, Hasenberg M, Voortmann S, Jastrow H, Dörrie J, Schaft N, Kraner M, Doehner K, Sodeik B, Steinkasserer A, Heilingloh C
Zeitschrift: Journal of Cell Biology
Jahr der Veröffentlichung: 2019
Band: 218
Heftnummer: 2
ISSN: 0021-9525


Abstract

Dendritic cells (DCs) are crucial for the induction of potent antiviral immune responses. In contrast to immature DCs (iDCs), mature DCs (mDCs) are not permissive for infection with herpes simplex virus type 1 (HSV-1). Here, we demonstrate that HSV-1 infection of iDCs and mDCs induces autophagy, which promotes the degradation of lamin A/C, B1, and B2 in iDCs only. This in turn facilitates the nuclear egress of progeny viral capsids and thus the formation of new infectious particles. In contrast, lamin protein levels remain stable in HSV-1-infected mDCs due to an inefficient autophagic flux. Elevated protein levels of KIF1B and KIF2A in mDCs inhibited lamin degradation, likely by hampering autophagosome-lysosome fusion. Therefore, in mDCs, fewer progeny capsids were released from the nuclei into the cytosol, and fewer infectious virions were assembled. We hypothesize that inhibition of autophagic lamin degradation in mDCs represents a very powerful cellular counterstrike to inhibit the production of progeny virus and thus viral spread.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Dörrie, Jan PD Dr.
Hautklinik
Düthorn, Alexandra
Immunmodulatorische Abteilung in der Hautklinik
Immunmodulatorische Abteilung in der Hautklinik
Kraner, Max Dr.
Lehrstuhl für Biochemie
Steinkasserer, Alexander Prof. Dr.
Professur für Experimentelle Dermatologie


Einrichtungen weiterer Autorinnen und Autoren

Hannover Medical School / Medizinische Hochschule Hannover (MHH)
Universität Duisburg-Essen (UDE)
Universitätsklinikum Essen


Zitierweisen

APA:
Turan, A., Grosche, L., Krawczyk, A., Mühl-Zürbes, P., Drassner, C., Düthorn, A.,... Heilingloh, C. (2019). Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1. Journal of Cell Biology, 218(2). https://dx.doi.org/10.1083/jcb.201801151

MLA:
Turan, Aykut, et al. "Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1." Journal of Cell Biology 218.2 (2019).

BibTeX: 

Zuletzt aktualisiert 2019-27-02 um 15:23