Exploiting enzyme promiscuity to shape plant specialized metabolism

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Kreis W, Munkert J
Zeitschrift: Journal of Experimental Botany
Jahr der Veröffentlichung: 2019
Band: 70
Heftnummer: 5
Seitenbereich: 1435-1445
ISSN: 0022-0957
Sprache: Englisch


The amazing variability of plant metabolism and its rapid divergence during evolution pose fundamental questions as to the driving forces, mechanisms and players in metabolic differentiation. This review examines concepts that help us understand adaptive pathway evolution, with a particular emphasis on plant specialized metabolism, previously often termed secondary metabolism. Following a general introduction to pathway and metabolite evolution the focus is directed to enzyme promiscuity and its classification. Promiscuous enzymes (or substrates), ‘silent’ elements of the metabolome and the metabolic underground, may be used and combined to evolve ‘new’ metabolic pathways. It appears that new pathways are rarely designed from scratch, but instead emerge from ‘floppy’ enzymes and elements of a ‘messy’ metabolism, in this way generating a range of metabolites some of which may provide benefits to the plant.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kreis, Wolfgang Prof. Dr.
Lehrstuhl für Pharmazeutische Biologie
Munkert, Jennifer Dr.
Lehrstuhl für Pharmazeutische Biologie


Kreis, W., & Munkert, J. (2019). Exploiting enzyme promiscuity to shape plant specialized metabolism. Journal of Experimental Botany, 70(5), 1435-1445. https://dx.doi.org/10.1093/jxb/erz025

Kreis, Wolfgang, and Jennifer Munkert. "Exploiting enzyme promiscuity to shape plant specialized metabolism." Journal of Experimental Botany 70.5 (2019): 1435-1445.


Zuletzt aktualisiert 2019-27-05 um 15:53