Model of dissolution in the framework of tissue engineering and drug delivery.
Sanz-Herrera JA, Soria L, Reina-Romo E, Torres Y, Boccaccini AR (2018)
Publication Status: Published
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 17
Pages Range: 1331-1341
Journal Issue: 5
DOI: 10.1007/s10237-018-1029-4
Abstract
Dissolution phenomena are ubiquitously present in biomaterials in many different fields. Despite the advantages of simulation-based design of biomaterials in medical applications, additional efforts are needed to derive reliable models which describe the process of dissolution. A phenomenologically based model, available for simulation of dissolution in biomaterials, is introduced in this paper. The model turns into a set of reaction-diffusion equations implemented in a finite element numerical framework. First, a parametric analysis is conducted in order to explore the role of model parameters on the overall dissolution process. Then, the model is calibrated and validated versus a straightforward but rigorous experimental setup. Results show that the mathematical model macroscopically reproduces the main physicochemical phenomena that take place in the tests, corroborating its usefulness for design of biomaterials in the tissue engineering and drug delivery research areas.
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Spain (ES)How to cite
APA:
Sanz-Herrera, J.A., Soria, L., Reina-Romo, E., Torres, Y., & Boccaccini, A.R. (2018). Model of dissolution in the framework of tissue engineering and drug delivery. Biomechanics and Modeling in Mechanobiology, 17(5), 1331-1341. https://dx.doi.org/10.1007/s10237-018-1029-4
MLA:
Sanz-Herrera, J. A., et al. "Model of dissolution in the framework of tissue engineering and drug delivery." Biomechanics and Modeling in Mechanobiology 17.5 (2018): 1331-1341.
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