Current knowledge about the impact of microgravity on the proteome

Strauch S, Grimm D, Corydon TJ, Krueger M, Bauer J, Lebert M, Wise P, Infanger M, Richter P (2019)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2019

Journal

Expert Review of Proteomics Expert Reviews (formerly Future Drugs)

Publisher: TAYLOR & FRANCIS LTD

Book Volume: 16

Pages Range: 5-16

Journal Issue: 1

DOI: 10.1080/14789450.2019.1550362

Abstract

Introduction: Microgravity (mu g) is an extreme stressor for plants, animals, and humans and influences biological systems. Humans in space experience various health problems during and after a long-term stay in orbit. Various studies have demonstrated structural alterations and molecular biological changes within the cellular milieu of plants, bacteria, microorganisms, animals, and cells. These data were obtained by proteomics investigations applied in gravitational biology to elucidate changes in the proteome occurring when cells or organisms were exposed to real mu g (r-mu g) and simulated mu g (s-mu g). Areas covered: In this review, we summarize the current knowledge about the impact of mu g on the proteome in plants, animals, and human cells. The literature suggests that mu g impacts the proteome and thus various biological processes such as angiogenesis, apoptosis, cell adhesion, cytoskeleton, extracellular matrix proteins, migration, proliferation, stress response, and signal transduction. The changes in cellular function depend on the respective cell type. Expert commentary: This data is important for the topics of gravitational biology, tissue engineering, cancer research, and translational regenerative medicine. Moreover, it may provide new ideas for countermeasures to protect the health of future space travelers.

Authors with CRIS profile

Sebastian Strauch Lehrstuhl für Zellbiologie Michael Lebert Lehrstuhl für Zellbiologie Peter Richter Lehrstuhl für Zellbiologie

Involved external institutions

Aarhus University DK Denmark (DK) Charles R. Drew University of Medicine and Science (CDU) US United States (USA) (US) Otto-von-Guericke-Universität Magdeburg DE Germany (DE) Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry DE Germany (DE)

How to cite

APA:

Strauch, S., Grimm, D., Corydon, T.J., Krueger, M., Bauer, J., Lebert, M.,... Richter, P. (2019). Current knowledge about the impact of microgravity on the proteome. Expert Review of Proteomics, 16(1), 5-16. https://dx.doi.org/10.1080/14789450.2019.1550362

MLA:

Strauch, Sebastian, et al. "Current knowledge about the impact of microgravity on the proteome." Expert Review of Proteomics 16.1 (2019): 5-16.

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