APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Klein S, Wegmann M, Distel L, Neuhuber W, Kryschi C
Zeitschrift: Biochemical and Biophysical Research Communications
Jahr der Veröffentlichung: 2018
Band: 498
Heftnummer: 4
Seitenbereich: 855-861
ISSN: 0006-291X


Abstract

Silicon nanoparticles with sizes between were synthesized through wet-chemistry procedures using diverse phase transfer reagents. On the other hand, the preparation of iron-doped silicon nanoparticles was carried out using the precursor Na4Si4 containing 5% Fe. Biocompatibility of all silicon nanoparticle samples was achieved by surface-stabilizing with (3-aminopropyl)triethoxysilane. These surface structures provided positive surface charges which facilitated electrostatic binding to the negatively charged biological membranes. The mode of interaction with membranes, being either incorporation or just attachment, was found to depend on the nanoparticle size. The smallest silicon nanoparticles (ca. 1.5 nm) were embedded in the mitochondrial membrane in MCF-7 cells. When interacting with X-rays these silicon nanoparticles were observed to enhance the superoxide formation upon depolarizing the mitochondrial membrane. X-ray irradiation of MCF-7 cells loaded with the larger silicon nanoparticles was shown to increase the intracellular singlet oxygen generation. The doping of the silicon nanoparticles with iron led to additional production of hydroxyl radicals via the Fenton reaction.


FAU-Autoren / FAU-Herausgeber

Distel, Luitpold Prof. Dr.
Strahlenklinik
Klein, Stefanie Dr.
Professur für Physikalische Chemie
Kryschi, Carola Prof. Dr.
Professur für Physikalische Chemie
Neuhuber, Winfried Prof. Dr.
Lehrstuhl für Anatomie und Zellbiologie
Wegmann, Marc
Lehrstuhl für Physikalische Chemie I


Zitierweisen

APA:
Klein, S., Wegmann, M., Distel, L., Neuhuber, W., & Kryschi, C. (2018). APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy. Biochemical and Biophysical Research Communications, 498(4), 855-861. https://dx.doi.org/10.1016/j.bbrc.2018.03.070

MLA:
Klein, Stefanie, et al. "APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy." Biochemical and Biophysical Research Communications 498.4 (2018): 855-861.

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Zuletzt aktualisiert 2019-15-01 um 04:08