G-Protein coupled receptors: answers from simulations

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Clark T
Zeitschrift: Beilstein Journal of Organic Chemistry
Verlag: BEILSTEIN-INSTITUT
Jahr der Veröffentlichung: 2017
Band: 13
Seitenbereich: 1071-1078
ISSN: 1860-5397


Abstract

Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs). In this field, MD simulations are unusually important as, because of the difficult experimental situation, they often offer the only opportunity to determine structural and mechanistic features in atomistic detail. Modern combinations of soft-and hardware have made MD simulations a powerful tool in GPCR research. This is important because GPCRs are targeted by approximately half of the drugs on the market, so that computer-aided drug design plays a major role in GPCR research.


FAU-Autoren / FAU-Herausgeber

Clark, Timothy apl. Prof. Dr.
Computer-Chemie-Centrum


Zitierweisen

APA:
Clark, T. (2017). G-Protein coupled receptors: answers from simulations. Beilstein Journal of Organic Chemistry, 13, 1071-1078. https://dx.doi.org/10.3762/bjoc.13.106

MLA:
Clark, Timothy. "G-Protein coupled receptors: answers from simulations." Beilstein Journal of Organic Chemistry 13 (2017): 1071-1078.

BibTeX: 

Zuletzt aktualisiert 2019-09-01 um 09:38