Clark T (2017)
Publication Status: Published
Publication Type: Journal article
Publication year: 2017
Publisher: BEILSTEIN-INSTITUT
Book Volume: 13
Pages Range: 1071-1078
DOI: 10.3762/bjoc.13.106
Molecular-dynamics (MD) simulations are playing an increasingly important role in research into the modes of action of G-protein coupled receptors (GPCRs). In this field, MD simulations are unusually important as, because of the difficult experimental situation, they often offer the only opportunity to determine structural and mechanistic features in atomistic detail. Modern combinations of soft-and hardware have made MD simulations a powerful tool in GPCR research. This is important because GPCRs are targeted by approximately half of the drugs on the market, so that computer-aided drug design plays a major role in GPCR research.
APA:
Clark, T. (2017). G-Protein coupled receptors: answers from simulations. Beilstein Journal of Organic Chemistry, 13, 1071-1078. https://dx.doi.org/10.3762/bjoc.13.106
MLA:
Clark, Timothy. "G-Protein coupled receptors: answers from simulations." Beilstein Journal of Organic Chemistry 13 (2017): 1071-1078.
BibTeX: Download